Saints in the Shadow Empyre

Every single follower of St. Cuthbert has a personally-chosen, particularly inspirational Patron Saint. This is part of Confirmation, and the devout take that saint's name and add it to their own (ie, John Louis Christopher Campbell.) The faithful pray not only to Cuthbert, but to his mother Mary (a saint) asking that she plead a particular case or desire to her son on their behalf. Prayers to saints work in much the same way, although usually involving matters perceived to be somewhat beneath the glory of Mary and Cuthbert, such as, "Saint James, please grant my ship fair weather for the crossing of the Inner Sea, "Saint George, give me the strength to fight valiantly against this minotaur," as opposed to, "Saint Cuthbert, I ask that you look kindly upon my recently-departed husband and welcome him into Heaven, rather than cast him into the flames of a Hell he so richly deserves." In the former case, it is frequently the saint themselves who answer the prayer in some subtle way, or decline to do so.
People choose Patron Saints for a wide variety of reasons. Having such a patron does not restrict the prayerful from asking for help and guidance from other saints... quite the contrary, and there are many especially devout Cuthbertians who pray to many saints on a regular basis. The Patron Saint, however, holds a special place within the heart of the prayerful, and their name and image frequently decorates homes, armor, weapons, banners and jewelry. It is often a tradition for a particular saint to be the family patron, with their name and image appearing in the family's coat of arms. Regardless of who is chosen as a patron, St. Cuthbert remains first and foremost in prayer and worship as the savior. Deo Gratias (thanks be to God.)

In campaign terms, saints work as follows;
First, a person praying to a saint must truly mean it, be Good in alignment (and a follower of Cuthbert) and at least somewhat devout. Trying for help from a saint simply to improve one's odds or work an angle, while not really respecting their divinity, is doomed to failure.
Next, the involved saint must be related in some way to the prayed-for result or task. DM discretion applies.
Making a simple prayer is a Free Action, and can proceed once the first two requirements are met.
Oremus (let us pray.) A saint's prayer spoken aloud, with conviction, to a Patron Saint has a 1-2 in 10 chance of success, resulting in a +1 modifier to whatever chance, task, action, skill or outcome is desired. A roll of 3-10 simply means the prayer is not answered, for whatever reason. A silent prayer has a 1 in 10 chance of similar success (Saints like to hear the faithful pray aloud, and display their devotion for all to hear.)
A verbal prayer to a non-Patron Saint has a 1-2 in 20 chance of success (a +1 modifier) and a silent prayer has a 1 in 20 chance,
There are no glorious visions or trumpeting angels to accompany a success, and no miraculous events (except in extreme circumstances adjudicated by the DM), simply the +1 modifier and a feeling that the saint has smiled upon them.
Saints welcome every prayer which comes their way, whether they grant the request or not, and for the especially devout the DM can increase the chance of success or bump up the modifier for particularly-liked devotees. In rare instances, the saint may even reveal themselves through a sign or even a vision. These moments are reserved for the truly faithful.

In all cases, it is the DM who decides the relevance of any given request, whether or not it is granted and to what extent, and how the petitioned saint views the asking party. Characters may convince themselves they are in excellent standing with a saint, but it is the saint themselves (the DM) who makes that decision. Woe unto the character who is so prideful and arrogant to think they have an inside track and are "owed" special favor from a divine being.

The following is a list of the saints of Cuthbert in the campaign, and their related areas of patronage. Particular deeds of note are in bold. Clerics and paladins should have ready access to this list, as it would have been drilled into them during their seminary and training time.

NOTE: 90% of the following is historically and religiously accurate, drawn from the Code of Canon Law, Title IV: Sacred Images and Relics, 1186-1187. The remaining 10% is a sprinkling of fantasy D&D and campaign-specific names and concepts.

SAINT PATRONAGE
Abascus Missionaries
Ambrose Candlemakers
Anastasia Weavers
Andronicus Silversmiths
Angelico Artists
Ansovinus Crops
Anthony Butchers, Basketmakers, Gravediggers, The Poor, Lost Articles
Augustine Miraculous Healing, Lakes & Streams, Serenity
Bartholomew Religious Scholars, Leatherworkers, Plasterers
Benedict Rogues, The Homeless
Bernadette Shepherds
Brigid Dairy Workers, Healers
Caanan Secret-Keepers
Capella Artillerymen, Bellmakers, Alchemists
Catherine of Notrenoc Paladins, Prostitutes, Philosophers, The Enslaved
Charles The Seminary, Innkeepers
Christopher Travelers, Booksellers, Gardeners
Claude Sculptors
Clement I Marbleworkers
Columba Poets
Damian Plane Travelers, Exorcists, Those who Fight the Undead
Dissius Children
Dunston Blacksmiths, Goldsmiths, Traders
Dominic Astronomers, Altar Boys, Choir, The Falsely-Accused
Edward the Confessor Interrogators, Inquisitors
Elgius Jewelers
Elizabeth War, Death of Children
Elmo Mariners, Childbirth, Ammunition
Emmanuel The Lost
Enrico Martyred Castillian rebel of the Blessed Virgin. Patron Saint of Freedom Fighters. Only recognized unofficially by the Church of Cuthbert.
Equius IV Former Cardinal, Architect of the Basillica. Patron Saint of architects & Builders of churches.
Eustachius Hunters, Rangers
Francis Merchants, Animals, The Forest, Passiveness
Gabriel the Archangel Clerics, Messengers
Genesius Theatrical Performers
George Soldiers, Rangers, Fighters
Gregory Musicians, Teachers
Isidore Farmers, Laborers
James Armorers, Tailors, Hatmakers, Pilgrims, Travelers
Jerome Librarians, Students, Orphans
John Judges, Priests, Authors, The Baptism, Mystics
Joseph Carpenters, Fathers, Justice, Dying, Undertakers
Jude Lost & Desperate Causes
Lawrence Cooks, Fire
Lucius Authors, Bricklayers, Orators
Luke Healers, Glassworkers, Painters
Maria Caravans, Merchant Vessels
Marin Monk of Opus Dei, Teacher of St. Rosalyn. Patron Saint of Combat Instructors.
Mark Judges, Scribes, Prisoners, The Seminary
Martin of Tours Horsemen
Mary of Coregg Mother of Cuthbert. Patron Saint of Mothers, Mercy, The Ascension
Matthew Moneychangers, Tax Collectors
Matthias Tavernkeepers, Alcoholism
Maurice Infantrymen, Swordsmiths
Michael the Archangel Highest among the Angels, Champion of Cuthbert. Patron Saint of Wrath, Flight, Weather, Watchmen
Napoli Mariners
Nicholas Brewers, Brides, Souls in Purgatory
Patrick Drove the Wyrms from Cae'Ragh. Patron Saint of Celts, Dragonslayers, Engineers
Peter The First Disciple. Patron Saint of Fishermen, Longevity
Raphael the Archangel Love
Rosalyn of Madrigal Founder of the Madrigala. Patron Saint of the Madrigala, Missionaries, The Weak & Oppressed
Silas I First Cardinal of St. Cuthbert. Patron Saint of Leadership
Stephen Stonemasons
Thomas Court Proceedings, Students
Valentine Lovers, Greetings
Victorius Former Emperor, Ended Persecution of "Blessed Virgin Heretics." Patron Saint of Diplomats, Peacemakers
Vincent Winemakers, Charity, The Sick
Y'ves Gatekeepers, Magistrates, Castles, Fortifications